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Chaya Lindner is a teenager living in Nazi-occupied Poland. Simply being Jewish places her in danger of being killed or sent to the camps. After her little sister is taken away, her younger brother disappears, and her parents all but give up hope, Chaya is determined to make a difference. Using forged papers and her fair features, Chaya becomes a courier and travels between the Jewish ghettos of Poland, smuggling food, papers, and even people. Soon Chaya joins a resistance cell that runs raids on the Nazis' supplies. But after a mission goes terribly wrong, Chaya's network shatters. She is alone and unsure of where to go, until Esther, a member of her cell, finds her and delivers a message that chills Chaya to her core, and sends her on a journey toward an even larger uprising in the works -- in the Warsaw Ghetto. Though the Jewish resistance never had much of a chance against the Nazis, they were determined to save as many lives as possible, and to live -- or die -- with honor.
One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs. This book presents new and important research in this field.
Plant growth and productivity are limited in many areas of the world by a wide variety of environmental stresses. This book discusses progress made toward the major goal of uncovering the plant resistance mechanisms to biotic and abiotic stresses; the purpose being to utilise this knowledge in genetic modification of plants for achieving improved stress resistance. This volume achieves a new synthesis in considering the mechanisms of resistance at various levels of organisation -- from individual cells and tissues, through whole plants, to communities. Chapters are written by internationally acknowledged experts, who have a wealth of research and teaching experience. With comprehensive and up-to-date coverage, this book analyses many outstanding problems and poses important questions for future research.
Plant-pathogen interactions is a rapidly developing area among the plant sciences. Molecular genetics has provided the tools to analyse and manipulate mechanisms of pathogenicity and resistance responses and has facilitated their study from the population to the molecular level. The book brings together the views of experts in the field and provides an overview of the genetic basis of interactions between fungi, bacteria, viruses and their host plants, the triggering of plant defences and the complex array of plant responses to stop pathogen invasion, as well as possible applications for improved plant protection. The chapters are organised and written to make an advanced textbook rather than simply a collection of reviews or something resembling conference proceedings. Thus, authors have largely concentrated on a didactic approach and the book should remain useable for several years in spite of the rapid progress in research. The text is aimed at advanced students in the field of plant pathology as well as researchers requiring an integrated picture of plant resistance to pathogens.
High-performance steels and aluminum alloys pose significant challenges to resistance welding processes. Unfortunately for students in materials science, metallurgy, and manufacturing, most available books provide only a superficial treatment of resistance spot welding. Surveying the topic in a scientific and systematic manner, Resistance Welding: Fundamentals and Applications supplies practical insight into every aspect of the field. This book comprehensively examines every aspect of resistance welding, from metallurgy and fundamental physical processes, such as electrothermal processes and discontinuities, to mechanical testing, process monitoring and control, weld quality and inspection, expulsion, and numerical simulation. The authors consider the influence of mechanical characteristics of welding machines and emphasize statistical design, analysis, and inference in resistance welding research, enabling students to conduct their own investigations. They present state-of-the-art research results from their own studies as well as from other leading experts, and the text's many examples are derived from real experiments. Case studies and nearly 300 figures illustrate the concepts. Resistance Welding: Fundamentals and Applications imparts a fundamental understanding of resistance welding processes and phenomena that empowers students to approach high-performance steels, aluminum alloys, and other new materials with confidence. It is an ideal upper-level undergraduate or graduate text for courses in assembly and joining processes, fundamentals of welding, and manufacturing processes.
Until very recently questions of resistance seemed straightforward, addressed in terms of an analysis of power. This book demonstrates how new, radical geographies of resistance emerge, develop and operate. Radical cultural politics, exemplified by the black, feminist and gay liberation, has developed struggles to turn sites of oppression and discrimination into spaces of resistance. Post-colonial and queer theory have opened up new political spaces. Whether resistance is an act of transgression (crossing borders), opposition (such as constructing barricades), or everyday endurance (staying in place), these are geographies where space is constitutive of the social. Leading contemporary geographers draw on material from around the world, including Israel, Nepal, Canada, Philippines, Australia and Nigeria. Recasting current themes in critical human geography - politics, identity and place - the contributors introduce unexplored notions of resistance, offering exciting insights for those exploring social, cultural, urban, political and development issues in different worlds of change.
Covering the use of elastic resistance bands and tubes, this work includes the scientific applications and exercise applications for different areas of the body, and sport-specific applications for ten different sports.
Focusing specifically on arthropods, this book provides a comprehensive review of relevant issues in pesticide resistance. It includes listings and references to documented reports of resistance from around the world, as well as discussions on the mechanisms and evolution of resistance and management techniques.